- General Drug Summary
- Description
- A widely used local anesthetic agent. [PubChem]
- Also Known As
- (+-)-Bupivacaine; Bloqueina; Bupivacaina [INN-Spanish]; Bupivacaine HCL; Bupivacaine HCL KIT; Bupivacainum [INN-Latin]; cBupivacaine; DL-Bupivacaine; DUR-843; LAC-43
- Categories
- Anesthetics, Local
- Structure
- Summary In Neonatal Jaundice
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2 record(s) for Bupivacaine Adverse Event in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 4000759
- Bupivacaine
- Adverse Event
- Clinical Trial
- Summary
- May be related to the observations that these agents cross the placenta, bind to the red cell membrane and reduce its filterability, resulting in shortened red cell survival.
- Bupivacaine alters red blood cell properties: a possible explanation for neonatal jaundice associated with maternal anesthesia. Pediatric research, 1985 Apr [Go to PubMed]
- Cord blood was incubated with lidocaine, mepivacaine, bupivacaine, or buffer and red blood cell filterability was determined. Only bupivacaine at either 1 or 2 micrograms/ml prolonged filterability by an average of 58 to 65% over red cells treated with buffer alone. Tritiated bupivacaine was bound to a greater extent to red cell ghosts from cord blood (24.6 +/- 5.8%) than to adult red cell ghosts (14.6 +/- 2.6%). Finally, we determined red cell survival in 13-day-old rats injected with bupivacaine or buffer. At 2 h after injection, buffer-treated animals had a red cell survival of 96.9 +/- 3.3%, whereas 2-h survival was reduced to 82.6 +/- 8.7% for the animals injected with bupivacaine. Our results suggest that the neonatal jaundice associated with maternal anesthesia, especially bupivacaine, may be related to the observations that these agents cross the placenta, bind to the red cell membrane and reduce its filterability, resulting in shortened red cell survival.
- 3116476
- Bupivacaine
- Adverse Event
- Clinical Trial
- Summary
- Bupivacaine and Neonatal jaundice does not have a causative connection.
- Effect of epidural analgesia with bupivacaine hydrochloride on neonatal bilirubin production. Obstetrics and gynecology, 1987 Nov [Go to PubMed]
- We evaluated the rate of bilirubin production in vivo in newborns whose mothers received an epidural block with bupivacaine hydrochloride during labor and delivery. Bilirubin production was estimated in 23 full-term newborns whose mothers were treated with bupivacaine and in 20 controls by determining the end-tidal carbon monoxide concentration and the blood carboxyhemoglobin level corrected for ambient carbon monoxide. No significant difference was found between the mean end-tidal carbon monoxide concentrations for the bupivacaine-treated and the control groups (1.3 +/- 0.5 and 1.4 +/- 0.7 microL/kg/hour, respectively), or between the mean blood carboxyhemoglobin levels corrected for ambient carbon monoxide (0.54 +/- 0.17 and 0.52 +/- 0.18% saturation, respectively). These negative findings support the clinical studies, which have failed to demonstrate a causative connection between bupivacaine and neonatal jaundice.
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2 record(s) for Bupivacaine NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 11223650
- Bupivacaine
- NA
- NA
- Summary
- It is likely that anesthetic technique can be included among factors with possible influence on Neonatal jaundice.
- Can anesthesiologic strategies for caesarean section influence newborn jaundice? A retrospective and prospective study. Biology of the neonate, 2001 Feb [Go to PubMed]
- Neonatal jaundice is a frequent problem in neonatology and can be influenced by many factors. Our study arose from the clinical observation that among all newborns delivered by caesarean section in our center, some had a more intense physiological jaundice. We began by reviewing clinical anesthesiological case-sheets to ascertain whether this difference was linked to the use of different anesthesiologic strategies. We then performed a prospective study on healthy preterm and term newborns to verify this hypothesis.
We retrospectively considered all healthy term newborns with weight > 2,400 g delivered by caesarean section from January 1998 to May 1999. In the prospective studies we included healthy term and preterm newborns consecutively delivered by caesarean section from May 1999 to December 1999. We excluded preterm newborns with gestational age < 31 weeks and with weight < 1,400 g.
Both in retrospective and in prospective studies anesthetic agents employed were isoflurane (A), sevoflurane (B), or bupivacaine (C). The statistical comparison of the three groups in retrospective study confirmed the clinical observation: the total bilirubin levels were significantly higher in the isoflurane group than in the sevoflurane group (p = 0.0000) and bupivacaine group (p = 0.0002). Analysis of data from the prospective study on term newborns confirmed our previous results. In preterm infants total bilirubin is statistically higher in group A starting from 96 h postdelivery.
It is likely that anesthetic technique can be included among factors with possible influence on neonatal jaundice.
- 6122939
- Bupivacaine
- NA
- NA
- Summary
- There as a higher incidence of Neonatal jaundice in infants exposed to more bupivacaine.
The addition of large amounts of dextrose to intravenous fluids was harmful to the fetus and of no benefit to the mother.
- Fetal and neonatal hazards of maternal hydration with 5% dextrose before caesarean section. Lancet, 1982 May 22 [Go to PubMed]
- In a prospective randomised study, 47 fasting women undergoing elective caesarean section received one of the following three glucose regimens for prevention of hypotension before administration of epidural bupivacaine to produce anaesthesia from the T4 sensory level: (i) 150 ml of 5% dextrose in water (D5W) and 1000 ml normal saline (7.5 g dextrose); (ii) 150 ml of D5W, 350 ml of 5% dextrose in normal saline (D5NS), and 650 ml of normal saline (25 g dextrose); (iii) 150 ml D5W and 1000 ml D5NS (57.5 g dextrose). The maternal blood sugar at delivery was significantly raised in patients receiving 25 and 57.5 g of dextrose. 57.5 g of dextrose also raised the mean umbilical cord venous levels of glucose to 11.7 mmol/l and of insulin to 70 +/- 7 microU/ml, while decreasing glucagon to 24 +/- 5.3 pg/ml and arterial pH to 7.19 +/- 0.015 compared with the levels with 7.5 g dextrose. The raised insulin level caused neonatal hypoglycaemia (1.8 +/- 0.22 mmol/l) and delayed release of glucagon at 2 hours of age. There as a higher incidence of neonatal jaundice in infants exposed to 57.5 g of dextrose than in those exposed to 7.5 g. The addition of large amounts of dextrose to intravenous fluids was harmful to the fetus and of no benefit to the mother. Until a safe rate of administration is established, it is recommended that dextrose infusions immediately before delivery be limited to no more than 6 g/h.
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1 record(s) for Bupivacaine Not Effective to Patients in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 3207780
- Bupivacaine
- Not Effective to Patients
- Clinical Trial
- Summary
- negative findings support the clinical studies which have not demonstrated an association between epidural anesthesia with bupivacaine HCl and Neonatal jaundice.
- Effect of bupivacaine hydrochloride on bilirubin production in neonatal rats. Biology of the neonate, 1988 [Go to PubMed]
- The rate of bilirubin production was studied in 12-hour-old rats exposed to bupivacaine HCl by subcutaneous injection. The bilirubin production was estimated by measuring the excretion rate of carbon monoxide (VeCO) using an open flow-through system. No significant difference was found between the VeCO of bupivacaine HCl-treated and control animals, or between the levels of bilirubin in the pooled blood of treated (0.92 +/- 0.32 SE mg/dl) and control (1.0 +/- 0.28 SE mg/dl) animals. These negative findings support the clinical studies which have not demonstrated an association between epidural anesthesia with bupivacaine HCl and neonatal jaundice.
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1 record(s) for Bupivacaine Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 6868969
- Bupivacaine
- Effective in Inducing Remission
- Randomized Controlled Trial
- Summary
- Acts as analgesic agent.
- Effect of segmental epidural analgesia on neonatal serum bilirubin concentration and incidence of neonatal hyperbilirubinemia. Acta obstetricia et gynecologica Scandinavica, 1983 [Go to PubMed]
- Neonatal serum bilirubin levels were determined at the ages of 12 hrs, 2 days, 3 days, 4 days and 5 days in 80 infants. Forty-three mothers had received segmental epidural analgesia at the height of Th 10-12 for pain relief during the first stage of labor. The analgesic agent used was 0.5% bupivacaine. The individual doses were of 4 ml. Thirty-seven mothers served as a control group. The groups were further divided into smaller groups according to whether oxytocin was used for induction or acceleration of labor--or not. The results showed no statistically significant differences in the neonatal serum bilirubin levels at different times between the epidural and the control groups, whether oxytocin was used or not. Nor did the incidence of neonatal hyperbilirubinemia cases differ between the groups.