- General Drug Summary
- Description
- An alkylating agent having a selective immunosuppressive effect on bone marrow. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen. [PubChem]
- Also Known As
- Busulphan; Busulphane; Butanedioldimethanesulfonate; Buzulfan; Sulfabutin; Sulphabutin; Tetramethylene Dimethane Sulfonate; Tetramethylenester Kyseliny Methansulfonove
- Categories
- Myeloablative Agonis
- Structure
- Summary In Neonatal Jaundice
-
1 record(s) for Busulfan Effective in Maintaining Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 11041572
- Busulfan
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- Acts as a pre-treatment conbinded with cyclophosphamide in post-transplant.
- Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency. Bone marrow transplantation, 2000 Sep [Go to PubMed]
- We report the first successful use of BMT for the treatment of RBC pyruvate kinase (PK) deficiency in a boy who developed neonatal jaundice and severe transfusion-dependent hemolytic anemia a few months after birth. He received a BMT at the age of 5 from an HLA-identical sister who has normal PK activity after conditioning with busulfan and cyclophosphamide. The post-transplant course was uneventful. At present, 3 years after transplant, he is 8 years old and has a normal hemoglobin level and normal RBC PK activity without evidence of hemolysis. DNA analysis has confirmed full engraftment.