- General Drug Summary
- Description
- A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589)
- Also Known As
- Methyldiazepinone
- Categories
- Muscle Relaxants, Ce
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Diazepam NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- Summary
- combination therapy of diazepam and fenoterol a significant number of the infants developed Neonatal jaundice.
- [Investigation on the influence of a tocolytic treatment of pregnant women with diazepam and fenoterol on the bilirubin levels and apgar score of newborn (author's transl)]. Klinische Pädiatrie, 1979 Jan [Go to PubMed]
- In a retrospective study of 2618 pregnant women we examined the influence of diazepam monotherapy as well as the combination of diazepam and fenoterol on the bilirubin concentrations and Apgar scores of the newborn children. In the diazepam-treated group 17-27% of the newborns showed Apgar scores of 6 or less. In the group treated with diazepam and fenoterol, 66-68% of the newborn had Apgar scores of 6 or less. The effect of diazepam on the bilirubin levels appears to depend on the dose and duration of the diazepam treatment: low, short term diazepam doses cause a slight bilirubin increase, while higher diazepam doses cause a reduction of the bilirubin levels. Following the combination therapy of diazepam and fenoterol a significant number of the infants developed neonatal jaundice. Due to the fact that following the combination therapy the diazepam concentration of the newborns were higher than following the monotherapy, we ascribe the greater frequency of the low Apgar values and also possibly the larger blirubin increase to the higher diazepam concentration caused by fenoterol.
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2 record(s) for Diazepam Adverse Event in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 626518
- Diazepam
- Adverse Event
- Review
- Summary
- serum bilirubin concentrations are influenced by these factors: administration to the mother of promethazine hydrochloride, reserpine, chloral hydrate, barbiturates, narcotic agents, diazepam, oxytocin, aspirin, and phenytoin sodium.
- Factors influencing jaundice in immigrant Greek infants. Archives of disease in childhood, 1978 Jan [Go to PubMed]
- A study of 887 consecutively born immigrant Greek and 220 Anglo-Saxon Australian infants has shown that serum bilirubin concentrations are influenced by these factors: breast feeding, delivery with forceps, gestation, birthweight, sex of the infant, presence of hypoxia, presence of blood group incompatibility, a positive direct Coombs's test, maternal sepis, and administration to the mother of promethazine hydrochloride, reserpine, chloral hydrate, barbiturates, narcotic agents, diazepam, oxytocin, aspirin, and phenytoin sodium. Apart from the administration of promethazine hydrochloride, reserpine, chloral hydrate, and quinalbarbitone sodium, only two factors, breast feeding and delivery by forceps, occured with different frequencies in the immigrant Greek and the Australian infants. Among the Greek infants with jaundice, there were few where the cause of the jaundice was inapparent. The immigrant Greek and Australian newborn populations were therefore remarkably similar. Since differences of frequency and everity of jaundice do exist in infants born in Greece, this difference must be lost when the parents emigrate, and therefore an environmental factor must be incriminated as the causative agent for jaundice of unknown origin in Greece.
- 6928283
- Diazepam
- Adverse Event
- Case Report
- Summary
- A drug that may results complications and should be emphasizesd the importance of reporting the adverse effects of it to central body.
- Systemic complications with intravenous diazepam. Oral surgery, oral medicine, and oral pathology, 1980 Feb [Go to PubMed]
- There are few published reports of complications following intravenous diazepam administration. However, more than 200 cases were reported to the United States Department of Health, Education and Welfare during a 7-year period. The systemic complications have been categorized by the authors, and common contributing factors are emphasized. The information obtained from these reports provides further knowledge of both the avoidance and the treatment of such complications and emphasizes the importance of reporting the adverse effects of any drug to a central body.
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2 record(s) for Diazepam Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 6893084
- Diazepam
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Be used in the therapy of Neonatal hyperbilirubinemia.
- Effect of hyperbilirubinemia on the pharmacokinetics of diazepam in the rat. Research communications in chemical pathology and , 1980 Apr [Go to PubMed]
- The pharmacokinetics of intravenously-administered diazepam have been studied in heterozygous (non-jaundiced) and homozygous (jaundiced) Gunn rats following single doses of 10 mg/Kg. Plasma concentration time course data from heterozygous and homozygous animals can be described adequately by biexponential equations. A faster plasma clearance rate (Clp) and shorter elimination half life (t 1/2) as well as reduced volumes of distribution [Vp and Vd(area)] were observed in homozygous animals. These potential effects of bilirubin on the distribution and elimination of diazepam should be considered if diazepam is to be used in the therapy of neonatal hyperbilirubinemia.
- 1133664
- Diazepam
- Effective in Inducing Remission
- Clinical Trial
- Summary
- The use of injectable diazepam, in appropriate quantities, poses no hazard to the newborn infant in terms of bilirubin toxicity.
- The effect of Na benzoate on serum bilirubin of the Gunn rat. The Journal of pediatrics, 1975 May [Go to PubMed]
- The administration of Na benzoate to grown and suckling Gunn rats in single doses of 7 and 35 mg/kg failed to significantly alter serum bilirubin concentrations. These doses are comparable to quantities of Na benzoate contained in injectable diazepam used therapeutically for newborn infants. Repeated doses of 7 mg/kg in the grown rat showed no effect, as well. A single dose of 100 or 200 mg/kg of Na benzoate and repeated doses of 35 mg/kg resulted in depressed serum bilirubin concentrations. The higher concentrations of Na benzoate, however, greatly exceed amounts contained in doses of diazepam recommended for clinical use in the human neonate. The data suggest that the use of injectable diazepam, in appropriate quantities, poses no hazard to the newborn infant in terms of bilirubin toxicity. The greater affinity for bilirubin of human albumin, than that of rat albumin, may further minimize the risk.