- General Drug Summary
- Description
- Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
- Also Known As
- Dinoprostone Prostaglandin E2; PGE2; Prostaglandin E2
- Categories
- Prostaglandins
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Dinoprostone Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 7052115
- Dinoprostone
- Effective in Inducing Remission
- Clinical Trial
- Summary
- PGE2 treated patients had a lower incidence of Neonatal jaundice.
- Induction of labour: a comparison of a single prostaglandin E2 vaginal tablet with amniotomy and intravenous oxytocin. British journal of obstetrics and gynaecology, 1982 Sep [Go to PubMed]
- In a randomized controlled study of 100 women of low parity and favourable induction features, induction of labour by means of a single vaginal tablet containing 3 mg of prostaglandin E2 (PGE2) was compared with the conventional method of amniotomy and intravenous oxytocin. Four of the patients (8%) who received the prostaglandin tablet required additional intravenous oxytocin to achieve delivery. The prostaglandin group had a longer mean overall induction-delivery interval but a shorter amniotomy-delivery interval than the oxytocin group. One patient in the PGE2 group and two in the oxytocin group required caesarean section. The PGE2 treated patients expressed a higher level of satisfaction with their method of induction, they required less analgesia, had less blood loss at delivery and their babies had a lower incidence of neonatal jaundice.
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1 record(s) for Dinoprostone Chemoprevention in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 556643
- Dinoprostone
- Chemoprevention
- Clinical Trial
- Summary
- Guidelines are suggested for the use of oral Prostaglandin E2 tablets to adequately control the labor process and prevent hypercontractility.
- Guidelines for the elective induction of labor with oral Prostaglandin E2. Obstetrics and gynecology, 1977 Jan [Go to PubMed]
- Fifty multiparous patients at 37 weeks or more of gestation with a vertex presentation and a Bishop score of 7 or more had labor induced with oral Prostaglandin E2 tablets. All responded and delivered vaginally. The induction to delivery time averaged 4 hours and 44 minutes. The average number of tablets required was 3.64. Four women experienced nausea and an additional 4 women had some vomiting. Two patients showed hypertonus and 11 had frequent contractions. Many progressed rapidly after they began active labor. There was no evidence of fetal distress. Guidelines are suggested for the use of oral Prostaglandin E2 tablets to adequately control the labor process and prevent hypercontractility.
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1 record(s) for Dinoprostone Not Effective to Patients in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 687542
- Dinoprostone
- Not Effective to Patients
- Clinical Trial
- Summary
- spontaneous labour and labour induced by (a) amniotomy, (b) amniotomy and simultaenous infusion of oxytocin, (c) amniotomy and simultaneous administration of oral prostaglandin E2 (PGE2). No significant difference in serum bilirubin levels in the first five days of life was found in the four groups.
- Neonatal serum bilirubin levels in spontaneous and induced labour. British journal of obstetrics and gynaecology, 1978 Aug [Go to PubMed]
- An investigation was made into the onset and severity of neonatal jaundice in 114 patients following spontaneous labour and labour induced by (a) amniotomy, (b) amniotomy and simultaenous infusion of oxytocin, (c) amniotomy and simultaneous administration of oral prostaglandin E2 (PGE2). No significant difference in serum bilirubin levels in the first five days of life was found in the four groups.