- General Drug Summary
- Description
- One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. [PubChem]
- Also Known As
- Dopamin; Dopamine HCl; Dophamine; Hydroxytyramin; Hydroxytyramine; Oxytyramine
- Categories
- Sympathomimetic
- Structure
- Summary In Neonatal Jaundice
-
2 record(s) for Dopamine Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 1200675
- Dopamine
- Effective in Inducing Remission
- In Vivo Study
- Summary
- A neurotransmitter of the catecholamine and phenethylamine families that plays a number of important roles in the human brain and body.
- Urinary phenolic acid and alcohol excretion in the newborn. Archives of disease in childhood, 1975 Aug [Go to PubMed]
- Mean urinary excretion values of some phenolic acids and alcohols have been measured by gas chromatography in 44 neonates (36 males, 6 females) during the first 2 days and days 3-7 of life, and the effect of prematurity and jaundice assessed. 4-Hydroxy-3-methoxymandelic acid (VMA) output rises immediately after birth in term but not in preterm infants. A similar increase in homovanillic acid (HVA) output was restricted to nonjaundiced term babies; in nonjaundiced preterm babies there was a steady rise during the first week. The ratio of HVA to VMA output was higher in these infants than in adults, suggesting a more rapid turnover of dopamine than adrenaline and noradrenaline. Unlike adult values, both HVA and VMA excretion values were directly related to urine volume, an observation perhaps related to renal immaturity. An unexplained reduction in HVA output in jaundiced as opposed to nonjaundiced infants was observed in the first 2 days of life. The ratio of 4-hydroxy-3-methoxyphenylglycol to VMA was about te same as in the adult. p-Hydroxyphenyl-lactic acid (p-HPLA), because of its superior stability, was measured in preference to p-hydroxyphenylpyruvic acid as an index of tyrosyluria. An output of 1 mg p-HPLA/24 h is proposed as the upper limit of normal. Prematurity was associated with a significant rise in p-HPLA output. A dramatic increase in excretion of this acid was noted in jaundiced, compared with nonjaundiced infants, presumably a manifestation of general enzyme immaturity.
- 6394025
- Dopamine
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Used in the management of hypotension in the early neonatal period and would solve hyperbilirubinemia by 3 1/2 weeks.
- Hepatic injury: a possible complication of dopamine infusion through an inappropriately placed umbilical vein catheter. American journal of perinatology, 1984 Jul [Go to PubMed]
- A 34-week preterm infant was evaluated for direct hyperbilirubinemia and hepatomegaly at 2 weeks of age. Dopamine had been used in the management of hypotension in the early neonatal period; the drug had been inappropriately infused into the right branch of the portal vein. Ultrasonography of the abdomen at 2 weeks showed mild hepatomegaly and a hypoechoic area in the right lobe of the liver posteriorly. Follow-up ultrasonogram at 3 months showed the liver to be of normal size and echogenicity. Hyperbilirubinemia was resolved by 3 1/2 weeks. No other problems were specifically related to the hepatic injury.
-
1 record(s) for Dopamine Effective in Maintaining Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 3987707
- Dopamine
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- Dopamine may have an important role to play in the homeostatic mechanisms of the newborn.
- Urinary catecholamine levels in the newborn infant. European journal of pediatrics, 1985 Jan [Go to PubMed]
- The urinary concentrations of dopamine, noradrenaline and adrenaline were measured by a radioenzymatic method in 212 full-term and premature newborns. The ranges, means and standard deviations from birth to 4 days + are presented. The excretion of dopamine was ten times that of noradrenaline or adrenaline. The absolute concentrations of each catecholamine were reduced as birth weight decreased. The values were increased in babies with fetal distress. Any changes found in hypoglycaemic or jaundiced infants were attributable to prematurity. Very high levels were found in a few infants given tolazoline. We speculate that the role of dopamine production and excretion in the newborn has been underestimated. Dopamine may have an important role to play in the homeostatic mechanisms of the newborn.