- General Drug Summary
- Description
- A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement therapy, it is not approved for use by the FDA or Health Canada. It is however available in the United States by prescription filled only by compounding pharmacies. It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
- Also Known As
- (16; α; ,17; β; )-estra-1,3,5(10)-triene-3,16,17-triol; 16-alpha-Hydroxyestradiol; 16alpha-hydroxyestradiol; 16; α; -hydroxyestradiol; Oestriol
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Estriol NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 878542
- Estriol
- NA
- Clinical Trial
- Summary
- Estriol elimination have no relative insufficiency with icteric newborns .
- [Bilirubin level and estrogen elimination in newborns (author's transl)]. Zeitschrift für Geburtshilfe und Perinatologie, 1977 Apr [Go to PubMed]
- Free estradiol and estriol was determined radioimmunologically in cord blood and in peripheral venous blood during the third, fifth and seventh day of life. The steroid level of a group of children with icterus neonatorum simplex were compared with an anicteric control group. In spite of the higher level of estriol in cord blood during the first week of life, estriol was eliminated much more rapidly than estradiol and independent of the bilirubin level. Given the same initial values for estradiol in cord blood of both control groups, the estradiol elimination rate was significantly slower in icteric newborns. The level of estradiol in cord blood was significantly higher in newborn males than in newborn females. A higher level in cord blood, however, does not increase the risk of a later newborn hyperbilirubinemia. Our findings tend to indicate that no etiologic importance should be attached to the amount of estradiol and estradiol to be eliminated, for the development of icterus neonatorum simplex. At the sae time, icteric newborns have a relative insufficiency in estradiol elimination but not, however, in estriol elimination.
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1 record(s) for Estriol Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 17710780
- Estriol
- Effective in Inducing Remission
- Randomized Controlled Trial
- Summary
- Used as a test to determine the general health of an unborn fetus.
- The relationship between perinatal outcome of singleton pregnancies and isolated highly elevated levels of maternal serum human chorionic gonadotropin at mid-gestation. The Israel Medical Association journal : IMAJ, 2007 Jul [Go to PubMed]
- The measurement of maternal serum human chorionic gonadotropin as a predictor of fetuses with Down syndrome has been in use since 1987.
To determine the correlation between extremely high levels of hCG at mid-gestation and maternal and fetal complications.
The study group consisted of 75 pregnant women with isolated high levels of hCG (> 4 MOM) at mid-gestation, and the control group comprised 75 randomly selected women with normal hCG levels (as well as normal alpha-fetoprotein and unconjugated estriol levels). In addition to demographic information, we collected data on fetal anomalies, chromosomal aberrations, pregnancy complications, and results of neonatal tests.
There was a significant increase in the frequency of fetal anomalies (detected by ultrasound), low birth weight and neonatal complications in the study group. We also found an increased rate of fetal/neonatal loss proportional to the increasing levels of hCG (up to 30% in levels exceeding 7 MOM).
Our study demonstrated an increased frequency of obstetric complications that was closely associated with high hCG levels. The study also raises questions about the accuracy of the Down syndrome probability equation in the presence of extremely high levels of hCG where data on the frequency of Down syndrome are severely limited.