- General Drug Summary
- Description
- A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem]
- Also Known As
- Absolute Alcohol; Absolute Ethanol; Alcohol; Alcohol Anhydrous; Alcohol, Dehydrated; Alcohol, Diluted; Alcool Ethylique; Alcool Etilico; Alkohol; Alkoholu Etylowego; Aminoethanol; Beta-Aminoethanol; Beta-Aminoethyl Alcohol; Beta-Ethanolamine; Beta-Hydroxyethylamine; Caswell No. 426; Dehydrated Ethanol; Denatured Alcohol; Denatured Ethanol; Etanolo; Ethanol 200 Proof; Ethanol Anhydrous; Ethanol Extra Pure; Ethyl Alcohol; Ethyl Alcohol Anhydrous; Ethyl Alcohol, Anhydrous; Ethyl Alcohol, Denatured; Ethyl Hydrate; Ethyl Hydroxide; Ethylol; Ethylolamine; HSDB 531; Methylcarbinol; USAF EK-1597
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Ethanol Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 23318962
- Ethanol
- Effective in Inducing Remission
- Review
- Summary
- The ethanol extract of Phyllanthus amarus root (EEPA) is able to decrease bilirubin level.
- Bilirubin clearance and antioxidant activities of ethanol extract of Phyllanthus amarus root in phenylhydrazine-induced neonatal jaundice in mice. Journal of physiology and biochemistry, 2013 Sep [Go to PubMed]
- The ability of ethanol extract of Phyllanthus amarus root (EEPA) to decrease bilirubin level and oxidative stress in phenylhydrazine-induced neonatal jaundice in mice was investigated. Administration of phenylhydrazine (75 mg/kg b.w.) significantly elevated total and unconjugated serum bilirubin level compared to control mice. EEPA (5, 10, and 20 mg/kg b.w., oral) dose-dependently reduced the bilirubin level. EEPA treatment also upregulated hepatic CAR and CYP3A1, accounting for its ability to facilitate bilirubin clearance. A single dose of EEPA (20 mg/kg b.w.) induced higher level of bilirubin clearance than phototherapy, widely used for treating neonatal jaundice. Furthermore, phenylhydrazine administration significantly increased MDA, protein carbonyl, and total thiol content and lowered the GSH level along with superoxide dismutase and catalase activity in erythrocyte compared to the control group. Single administration of EEPA (20 mg/kg b.w.) significantly reversed the trend. Presence of gallic acid, gntisic acid, and ortho-coumaric acid in EEPA was identified by HPLC analysis. Amongst these, the major phenolic constituent, gallic acid, exhibited significant bilirubin-lowering effect. These results suggested that P. amarus may be beneficial in reducing bilirubin level as well as oxidative stress in neonatal jaundice.
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1 record(s) for Ethanol Effective in Complication in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 401515
- Ethanol
- Effective in Complication
- Clinical Trial
- Summary
- Its bacteriocidal and antifungal action used for a treatment in control group.
- Hemoperfusion through albumin-conjugated agarose gel for the treatment of neonatal jaundice in premature rhesus monkeys. The Journal of laboratory and clinical medicine, 1977 Jan [Go to PubMed]
- Hemoperfusion through albumin-conjugated agarose gel (AAG) effectively removes bilirubin (BR) and other albumin-bound materials from whole blood or plasma. We have used this technique to treat neonatal jaundice in premature rhesus monkeys with a specially designated apparatus which permits continuous perfusion through one of four columns arranged in parallel while the others are sequentially washed with saline and regenerated with ethanol. Less than 15 per cent of the animal's blood volume is required in the extracorporeal circuit at any time. Results indicate that (1) compared with five control monkeys which had a peak BR concentration ([BR]) averaging approximately 4 mg./100 ml., six experimental monkeys showed a significant (p less than 0.01) reduction, averaging 60 per cent, in [BR] after each of two perfusions at approximately 20 and 26 hours of age; (2) AAG hemoperfusion was even more effective in lowering [BR] in monkeys with higher preperfusion concentrations produced by BR infusion (average reductio = 68 and 87 per cent at preperfusion concentrations of 11.9 and 24.2 mg./100 ml., respectively); and (3) overall, BR eluted from the column averaged 93 per cent of the estimated preperfusion plasma BR pool. Unlike previous studies in rats, perfused monkeys showed significant platelet losses, although it was possible to prevent these losses by the use of"
regional citrat"
during perfusion. These studies suggest that AAG hemoperfusion is effective in the treatment of neonatal jaundice, although potential problems such as sterility and platelet loss need further evaluation before it can be considered for human use.