- General Drug Summary
- Description
- A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (genetic translation). [PubChem]
- Categories
- Aminoglycosides
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Gentamicin NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 7344880
- Gentamicin
- NA
- Clinical Trial
- Summary
- the exchange transfusion procedure significantly increases the rate of gentamicin elimination. The decrement produced by the procedure may result in subtherapeutic concentrations, if the initial values are marginally efficacious.
- Effect of exchange transfusion on serum gentamicin concentrations. Developmental pharmacology and therapeutics, 1981 [Go to PubMed]
- To determine whether an exchange transfusion increases the rate of elimination of gentamicin, we measured drug (and bilirubin) concentration either before and during, or during and after a standard two-volume exchange procedure in 7 newborns. In an additional 5 infants, serum was obtained only on initiation and conclusion of the procedure. The mean decrement in serum gentamicin concentration with the procedure was 2.2 micrograms/ml; this was 25.7% of the original mean concentration. The mean elimination rate constant during the procedure was 0.342 h-1, a value significantly greater (p = 0.013) than the mean rate before or after the procedure, 0.104 h-1. We conclude that the exchange transfusion procedure significantly increases the rate of gentamicin elimination. The decrement produced by the procedure may result in subtherapeutic concentrations, if the initial values are marginally efficacious.
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1 record(s) for Gentamicin Effective in Complication in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 2380831
- Gentamicin
- Effective in Complication
- Clinical Trial
- Summary
- Suppress intestinal flora.
- Zinc protoporphyrin administration for suppression of increased bilirubin production by iatrogenic hemolysis in rhesus neonates. The Journal of pediatrics, 1990 Aug [Go to PubMed]
- We studied the effect of intravenous zinc protoporphyrin (ZnPP) administration on total body carbon monoxide excretion (VeCO), (an index of heme degradation), blood carboxyhemoglobin level, plasma bilirubin level, and tissue homogenate heme oxygenase activity 24 hours after delivery of rhesus neonates treated at 12 hours of age with heat-damaged erythrocytes (32 mumol heme/kg birth weight). All neonates were delivered by cesarean section and received ampicillin and gentamicin to suppress intestinal flora. The control group (n = 4) was treated with saline solution and ZnPP solvent; the erythrocyte-treated control group (n = 4) received erythrocytes and ZnPP solvent; and two experimental groups received erythrocytes and one dose of 10 (n = 3) or 40 (n = 4) mumol ZnPP/kg body weight, respectively. At 24 hours, administration of erythrocytes alone doubled the VeCO (p less than 0.05), carboxyhemoglobin level, (p less than 0.05), and plasma total bilirubin level (p less than 0.05). Treatment with ZnPP, 40 mumol/kgbody weight, caused a significant decrease in VeCO (p less than 0.05), carboxyhemoglobin (p less than 0.05), bilirubin (p less than 0.05), and spleen heme oxygenase (p less than 0.05). Treatment of the erythrocyte-loaded animals with ZnPP, 10 mumol/kg body weight, also significantly (p less than 0.05) lowered VeCO and spleen heme oxygenase activity but did not cause a significant lowering of blood carboxyhemoglobin or plasma bilirubin concentration. We conclude that ZnPP is an effective, dose-dependent in vivo inhibitor of heme oxygenase in the newborn rhesus with latrogenic hemolysis, and that it suppresses both bilirubin production and subsequent accumulation.
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1 record(s) for Gentamicin Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 2632996
- Gentamicin
- Effective in Inducing Remission
- In Vitro Study
- Summary
- Gentamicin is efficient for Neonatal jaundice with presumed sepsis.
- The first isolate of Tatumella ptyseos in Malaysia. The Malaysian journal of pathology, 1989 Aug [Go to PubMed]
- Tatumella ptyseos, the type species for the genus Tatumella, is a newly established member of the Family Enterobacteriaceae. It is a Gram-negative, oxidase negative, fermentative rod that grows on Mac Conkey agar. This first isolate was obtained from the blood culture of a neonate having neonatal jaundice with presumed sepsis. The organism was in vitro sensitive to Gentamicin, Chloramphenicol, Cotrimoxazole and Ampicillin. The patient was treated with Ampicillin and Gentamicin and recovered uneventfully.
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1 record(s) for Gentamicin Not Effective to Patients in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 784927
- Gentamicin
- Not Effective to Patients
- In Vivo Study
- Summary
- Gentamicin does not alter bilirubin-albumin binding.
- Gentamicin and albumin-bilirubin binding. An in vivo study. The Journal of pediatrics, 1976 Sep [Go to PubMed]
- Ten newborn infants were given gentamicin intramuscularly. Over a postinjection interval of 12 hours, no significant change occurred in the total binding capacity of serum albumin for bilirubin or in concentrations of serum bilirubin levels. There was no correlation between concentrations of serum gentamicin and the total binding capacity or serum bilirubin. This study provides in vivo data that supports recent in vitro experiments showing that gentamicin does not alter bilirubin-albumin binding.