- General Drug Summary
- Drug Name
- Hexachlorophene
- Description
- A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
- Categories
- Anti-Infective Agent
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Hexachlorophene Adverse Event in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 1137506
- Hexachlorophene
- Adverse Event
- Clinical Trial
- Summary
- Neurotoxic effects to human.
- Neurotoxicity of hexachlorophene in humans. II. A clinicopathological study of 46 premature infants. Archives of neurology, 1975 May [Go to PubMed]
- To assess neurotoxic effects of hexachlorophene in the human population previously shown to be most at risk, a blind clinicopathological analysis was made of all premature infants under 1,400 gm birth weight who survived at least four days and were examined by autopsy over a 7.5-year period. Repeated whole-body bathing of premature newborn infants in 3% hexachlorophene-bearing soap (undiluted pHisoHex) shows a significant statistical association with a vacuolar encephalopathy of the brain stem reticular formation. The prevalence of the vacuolar encephalopathy in premature infants on whom we have adequate brain stem histological information appears to be related to the number of exposures to hexachlorophene, the concentration of hexachlorophene, the thoroughness of rinsing, and other factors (including exposure to ultraviolet light).