- General Drug Summary
- Description
- Ibuprofen, a propionic acid derivative, is a prototypical nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
- Also Known As
- Ibuprophen; P-Isobutylhydratropic Acid; Para-Isobutylhydratropic Acid
- Categories
- Nonsteroidal Anti-in
- Structure
- Summary In Neonatal Jaundice
-
2 record(s) for Ibuprofen Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 20216106
- Ibuprofen
- Effective in Inducing Remission
- Clinical Trial
- Summary
- ibuprofen is a competitive displacer of bilirubin in vitro. Ibuprofen should be used with caution in premature infants with a significant hyperbilirubinemia.
- Displacement of bilirubin from albumin by ibuprofen in vitro. Pediatric research, 2010 Jun [Go to PubMed]
- Ibuprofen binds to plasma albumin and could interfere with the binding of bilirubin in jaundiced newborn infants. Most clinical studies have not shown increased concentrations of unbound bilirubin (UB) in plasma from infants treated with ibuprofen for a patent ductus arteriosus. However, studies in vitro have not been equally conclusive. Plasma were obtained from routine samples from jaundiced newborn infants and pooled. Total and UB were measured with the peroxidase method after addition of ibuprofen or sulfisoxazole as a known bilirubin displacer. Final ibuprofen concentrations varied from 0.43 to 2.6 mM. Bilirubin concentrations were varied from 176 to 708 microM by adding bilirubin to plasma samples. Ibuprofen caused a linear increase in UB up to +54% at a concentration of 1.8 mM, compared with an increase of 87% by sulfisoxazole (1.32 mM). A double reciprocal plot of molar concentrations of bound versus UB at bilirubin concentrations ranging from 176 to 708 microM showed a competitive displacement of biirubin by ibuprofen. The data indicate that ibuprofen is a competitive displacer of bilirubin in vitro. Ibuprofen should be used with caution in premature infants with a significant hyperbilirubinemia.
- 15001951
- Ibuprofen
- Effective in Inducing Remission
- Review
- Summary
- Close the ductus arteriosus in premature newborn infants.
- Effect of ibuprofen on bilirubin-albumin binding. The Journal of pediatrics, 2004 Mar [Go to PubMed]
- Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn infants.