- General Drug Summary
- Description
- A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry. [PubChem]
- Categories
- Sweetening Agents
- Structure
- Summary In Neonatal Jaundice
-
2 record(s) for Lactose NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 3989620
- Lactose
- NA
- Clinical Trial
- Summary
- Lactose malabsorption is not a cause of diarrhea during phototherapy.
- Lactose malabsorption is not a cause of diarrhea during phototherapy. Journal of pediatric gastroenterology and nutritio, 1985 Apr [Go to PubMed]
- Lactose malabsorption is not a cause of diarrhea during phototherapy. Jaundiced neonates under phototherapy develop diarrhea or loose stools during the treatment. These phenomena were attributed to an induced lactase deficiency caused by bilirubin breakdown products. We investigated lactose malabsorption in 59 neonates--29 normals and 30 jaundiced under phototherapy. Five-hour hydrogen breath tests were performed. Preprandial and postprandial (at 30, 60, 120, 180, 240, and 300 min) expired air samples were analyzed for hydrogen. Ten controls and five jaundiced neonates had positive hydrogen breath tests. Eighteen controls and 16 neonates under phototherapy had preprandial hydrogen (concentrations above 5 ppm). In our hands, lactase deficiency and lactose malabsorption were not induced by phototherapy. Lactase deficiency is therefore not the cause of diarrhea associated with phototherapy.
- 7368914
- Lactose
- NA
- Clinical Trial
- Summary
- Lactose malabsorption is not the usual cause of the reduced gut transit time during phototherapy .
- Gut transit time and lactose malabsorption during phototherapy. II. A study using raw milk from the mothers of the infants. Acta paediatrica Scandinavica, 1980 Jan [Go to PubMed]
- Thirty newborn infants with normal birth weight suffering from uncomplicated hyperbilirubinemia were studied. 15 infants received ordinary phototherapy and 15 intensive phototherapy (blue double light). All infants received their mothers' milk or fresh milk from mothers of other newborn infants of the same age. All infants had normal lactose tolerance test during the phototherapy, except one infant receiving ordinary transit time was relatively long. The gut transit time was significantly shorter in the infants treated with intensive phototherapy than in those treated with ordinary phototherapy without there being any significant difference in the increase in blood glucose by lactose tolerance tests. It is concluded that lactose malabsorption is not the usual cause of the reduced gut transit time during phototherapy even if the infants receive their mothers' milk.
-
2 record(s) for Lactose Effective in Maintaining Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 7368913
- Lactose
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- Lactose malabsorption can not reduce intestinal transit time,But is a rare complication of phototherapy.
- Gut transit time and lactose malabsorption during phototherapy. I. A study using lactose-free human mature milk. Acta paediatrica Scandinavica, 1980 Jan [Go to PubMed]
- Sixty newborn infants with normal birth weight suffering from uncomplicated hyperbilirubinemia were studied. They were fed human mature milk from which lactose had been eliminated, whereafter either sucrose (
"
sucrose mil"
) or lactose (
"
lactose mil"
) was added. 30 infants received ordinary phototherapy and 30 intensive phototherapy (blue double light). 15 in each group had"
sucrose mil"
and 15"
lactose mil"
. There was no significant difference between the increase in blood glucose (delta BS) by lactose tolerance tests performed before phototherapy (LTT1) and by those performed during phototherapy (LTT11), neither in infants treated with ordinary nor with intensive phototherapy. All infants had normal delta BS-LTT11, except one receiving ordinary phototherapy. There was no significant difference in gut transit time between infants having"
sucrose mil"
and infants having"
lactose mil"
, neither in those treated with ordinary nor with intensive phototherapy. Gut transit time was significantly shorter in infants treated with intensive phototherapy than in infants treated with ordinary phototherapy without there being any significant difference in delta BS-LTT11. The infant with flat LTT11 may have developed lactose malabsorption during the phototherapy. Thus, lactose malabsorption is not the usual cause of the reduced gut transit time during phototherapy and must be a rare complication in phototherapy.
- 2732639
- Lactose
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- Lactose formula has little role in newborn infants with hyperbilirubinemia during phototherapy.
- Effect of phototherapy on nutrients utilization in newborn infants with jaundice. Journal of the Medical Association of Thailand = C, 1989 Jan [Go to PubMed]
- The effect of phototherapy on digestion and absorption of nutrients was performed in 25 male, newborn infants with hyperbilirubinemia. The infants were divided into 2 groups; one group was fed with lactose formula whereas the other group received the non-lactose formula. The quantities of daily volume, fat and energy intakes of both groups were similar. Protein intake was significantly higher in the latter group. During 72-hours of phototherapy, there were decreases in serum bilirubin in all infants and mean weight change was decreased in infants fed with non-lactose formula. Treatment by phototherapy in jaundiced infants did not affect protein, fat and energy absorption. The presence of loose stool, lower stool pH and trace in reducing substances in some subjects fed with lactose formula suggests mild lactose intolerance. Prospective study in clinical trial needs to be further assessed and clarified on other nutrients such as amino acids and riboflavin status in these infants during phototherapy.
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1 record(s) for Lactose Adverse Event in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 831386
- Lactose
- Adverse Event
- Clinical Trial
- Summary
- Increased amounts of unconjugated bilirubin in the intestine of jaundiced infants during light-treatment inhibit the intestinal brush-border lactase.
- Temproary intestinal lactase deficiency in light-treated jaundiced infants. Acta paediatrica Scandinavica, 1977 Jan [Go to PubMed]
- The intestinal lactase activity in six newborn jaundiced light-treated infants with diarrhea and in eight normal controls were compared by lactose tolerance test (LTT). The ability to hydrolyze lactose was minimal in the jaundiced infants during light-treatment compared to the controls which could absorb lactose very well. Peroral intestinal biopsies were taken from the newborn jaundiced infants during light-treatment. By histochemical technique no intestinal lactase activity was found in these intestines. When the jaundiced infants with diarrhea were given lactose-free diet, the stools normalized. The effect was reversed when breast milk was given while the baby was still jaundiced and light-treated. These findings indicate that the increased amounts of unconjugated bilirubin in the intestine of jaundiced infants during light-treatment inhibit the intestinal brush-border lactase. When the icterus fades the lactase is again active. The practical consequence is to give light-treated infants lactose-free diet f they get diarrhea, and to reintroduce breast milk or other lactose containing diet when the baby is no longer icteric.