- General Drug Summary
- Drug Name
- Lysergic Acid Diethylamide
- Description
- Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action of LSD on brain chemistry, and varies according to the susceptibility of the individual to the disorder. Many emotionally intense experiences can lead to flashbacks when a person is reminded acutely of the original experience. However, not all published case reports of chronic flashbacks appear to describe an anxious hyper-vigilant state reminiscent of post-traumatic stress disorder.
- Also Known As
- (+)-LSD; (+)-lysergic acid diethylamide; 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide; Acid; Barrels; Bart simpson; Bartman; Beast; Big f; Blotter acid; Blue acid; Blue cheer; Blue mist; Blue star; Brown dots; California sunshine; Cherry top; Chief; Chocolate chips; Clearlight; Coffeinum; Contact lens; Cubes; Cupcakes; D-LSD; D-LSD-25; D-lysergic acid dethylamide; D-lysergic acid diethylamide; D-lysergic acid n,n-diethylamide; Delysid; Dextrolysergic acid diethylamide; Diethylamid kyseliny lysergove [czech]; Domes; Ergine; Fifty; Flats; Frogs; Gelatin chips; Greenies; Heavenly blue; LSD; LSD-25; Lucy in the sky with diamonds; Lysergamid; Lysergamide; Lysergaure diethylamid; Lysergic acid amide; Lysergic acid diethylamide-25; Lysergide; Lysergidum [inn-latin]; Mean green; Mellow yellow; Microdots; n,n-diethyl-(+)-lysergamide; N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide; N,n-diethyl-d-lysergamide; N,n-diethyllysergamide; Orange mushroom; Orange sunshine; Orange wedges; Owsley; Paper acid; Pearly gates; Purple haze; Purple microdot; Royal blue; Scapes; Spoonies; Strawberry fields; Sugar; Sugar lump; Sunshine; TABS; The hawk; Trippers; Ubergluben; Wedding bells; Wedges; White light; Window pane; Yellows; ZEN
- Categories
- Serotonin Agonists
- Groups
- illicit; withdrawn
- Structure
- Summary In Neonatal Jaundice
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2 record(s) for Lysergic Acid Diethylamide NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 3564940
- Lysergic Acid Diethylamide
- NA
- NA
- Summary
- The cholestatic effect could be mediated by an increase in the plasma amino acid concentration.
- Evidence for amino acid induced cholestasis in very-low-birth-weight infants with increasing enteral protein intake. Acta paediatrica Scandinavica, 1986 Sep [Go to PubMed]
- In the present investigation 32 very-low-birth-weight (VLBW) infants fed at three different levels of protein intake (2.92 g/kg/d from human milk, 3.22 and 4.06 g/kg/d from formula) were studied at the mean age of 21 days. Serum total alpha-amino nitrogen concentration correlated directly to total bile acid concentration. The serum and urine alpha-amino nitrogen and the serum bile acid concentration correlated with protein intake. The increase in protein intake was accompanied by a concomitant decrease in the intraluminal bile acid concentration in the AGA infants. The results offer indirect evidence of decreased bile flow in VLBW-infants on excessive oral protein intake. The cholestatic effect could be mediated by an increase in the plasma amino acid concentration.
- 4045632
- Lysergic Acid Diethylamide
- NA
- Clinical Trial
- Summary
- alteration in conjugated bile acid patterns of breast milk jaundice is related to an increased enterohepatic circulation of bile acids as well as biirubin in infants fed on breast milk that contains high amounts of taurine.
- Alterations of serum bile acid profile in breast-fed infants with prolonged jaundice. Journal of pediatric gastroenterology and nutritio, 1985 Oct [Go to PubMed]
- Serum bile acid conjugates in breast-fed infants with prolonged jaundice were analyzed by a newly developed procedure using high-performance liquid chromatography with fluorescence labeling. Major bile acids were cholate and chenodeoxycholate conjugates. Some of the breast-fed jaundiced infants had high levels of serum bile acid conjugates (greater than 25 mumol/L), but the mean levels of individual bile acid conjugates found in jaundiced breastfed infants were not significantly different from those in breast-fed infants without jaundice. The glycine- to taurine-conjugated bile acid ratio in breast-fed jaundiced infants was significantly lower than in breast-fed nonjaundiced infants or bottle-fed nonjaundiced infants. In breast-fed infants, the portion of taurine-conjugated bile acids increased in proportion to serum bilirubin levels. These findings suggest that alteration in conjugated bile acid patterns of breast milk jaundice is related to an increased enterohepatic circulation of bile acids as well as biirubin in infants fed on breast milk that contains high amounts of taurine.
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1 record(s) for Lysergic Acid Diethylamide Adverse Event in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 7180444
- Lysergic Acid Diethylamide
- Adverse Event
- Clinical Trial
- Summary
- bile acids compete with bilirubin for albumin binding
- Effect of phototherapy and exchange transfusion on primary bile acids in the serum of hyperbilirubinaemic newborns. Acta paediatrica Scandinavica, 1982 Sep [Go to PubMed]
- Serum primary bile acid (cholic (CA) and chenodeoxycholic (CDCA) acid) concentrations were measured in 14 preterm and 11 full-term hyperbilirubinaemic newborns at the beginning and end of, and 24 and 72 hours following phototherapy. Only in the preterm newborns with gestational ages of 35-38 weeks there was a significant decrease of mean serum bile acid concentrations which could be shown 72 hours after the beginning of phototherapy. It can be hypothesized that the decrease was a result of a direct effect of light on the excretory liver function. Serum CA and CDCA concentrations were also measured in 5 hyperbilirubinaemic newborns at the beginning and end, and 24, 48 and 72 hours after the end of exchange transfusion. Exchange transfusion caused a clear immediate decrease in the mean serum primary bile acid concentrations. However, on day 2 after exchange transfusion the mean serum concentration of CA was about 150% and that of CDCA about 110% of the initial values. The most hyperbilirubinaemic newborns had xtremely high primary bile acid serum concentrations before therapy. As bile acids compete with bilirubin for albumin binding it should be considered whether high bile acids in the serum of hyperbilirubinaemic newborns presuppose exchange transfusions.
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1 record(s) for Lysergic Acid Diethylamide Effective in Maintaining Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 843554
- Lysergic Acid Diethylamide
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- phototherapy with white light can cure neonatal jaundice
- Agar ingestion combined with phototherapy in jaundiced newborn infants. Biology of the neonate, 1977 [Go to PubMed]
- 49 jaundiced, nonimmunized newborn infants with a birth weight of more than 2,000 g were given phototherapy with white light for more than 36 h. The average period of treatment was 61 h. 24 infants received 250 mg agar at the beginning of each meal at 3-hour intervals during phototherapy. 25 infants received phototherapy only. Serum bilirubin levels were decreased similarly in both groups. It is concluded that ingestion of agar does not supplement the effect of phototherapy.
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1 record(s) for Lysergic Acid Diethylamide Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 1525269
- Lysergic Acid Diethylamide
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Standard white light phototherapy is usually adequatefor ABO-HD as well as non-haemolytic hyperbilirubinaemia. High intensity blue light would be preferable where a more rapid and greater response is desirable.
- Phototherapy for ABO haemolytic hyperbilirubinaemia. Biology of the neonate, 1992 [Go to PubMed]
- The efficacy of 'standard' daylight phototherapy and 'high intensity' blue light phototherapy for neonatal jaundice from ABO-HD, or of a non-haemolytic nature was evaluated. Altogether 77 full-term infants with ABO-HD and 3,020 with non-haemolytic jaundice were studied. Both groups of infants responded well to standard daylight phototherapy; the response in non-haemolytic hyperbilirubinaemia was significantly greater. High intensity blue light phototherapy was significantly more effective in reducing bilirubin levels than standard daylight phototherapy in both group of infants with no failure being encountered. Four infants with non-haemolytic jaundice did not respond adequately to white light (1.4/1,000); they needed high intensity blue light for adequate response. Bilirubin rebound was mild. Four infants in the blue light group needed a second exposure (28.3/1,000) compared with 20 in the white light group (6.9/1,000), a difference that was significant. Standard white light phototherapy is usually adequatefor ABO-HD as well as non-haemolytic hyperbilirubinaemia. High intensity blue light would be preferable where a more rapid and greater response is desirable.