- General Drug Summary
- Drug Name
- Methylphenobarbital
- Description
- A barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital. [PubChem]
- Also Known As
- Mephobarbital; Mephobarbitone; Methyl Phenobarbitone; Methylphenobarbitalum [INN-Latin]; Methylphenobarbitonum; Methylphenolbarbital; Methylphenylbarbituric acid; Metilfenobarbital [INN-Spanish]; Metilfenobarbitale [Dcit]; N-Ethylmethylphenylbarbituric acid; N-Methylethylphenylbarbituric acid; N-Methylphenobarbital; N-Methylphenolbarbitol
- Categories
- GABA Modulators
- Structure
- Summary In Neonatal Jaundice
-
1 record(s) for Methylphenobarbital Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 3241289
- Methylphenobarbital
- Effective in Inducing Remission
- Clinical Trial
- Summary
- methylphenobarbital (MPB)can prevent of metabolic hyperbilirubinemia of the newborn, which has less sedative effects than phenobarbital (PB)
- Induction of bilirubin-eliminating processes by methylphenobarbital in mature newborn babies. Journal of perinatal medicine, 1988 [Go to PubMed]
- In order to find a drug for the prevention of metabolic hyperbilirubinemia of the newborn, which has less sedative effects than phenobarbital (PB) the effect of methylphenobarbital (MPB) on the plasma bilirubin concentration of newborns was studied in a double blind trial. MPB (3 x 10 mg/kg on the first day) reduced the plasma bilirubin level in mature newborns on day four by 33% in comparison to those on placebo. The results justify further investigations in premature babies, who frequently suffer from disturbances which may facilitate the development of bilirubin encephalopathy.