- General Drug Summary
- Description
- An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
- Also Known As
- 2-Oxopropanoate; 2-Oxopropanoic acid; 2-Oxopropionic acid; a-Ketopropionic acid; Acetylformic acid; BTS; Pyroracemic acid; Pyruvate
- Groups
- approved; nutraceutical
- Structure
- Summary In Neonatal Jaundice
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2 record(s) for Pyruvic acid NA in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 2761512
- Pyruvic acid
- NA
- NA
- Summary
- erythrocyte pyruvate kinase deficiency is a cause of Neonatal jaundice
- Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia. Missouri medicine, 1989 Feb [Go to PubMed]
- Although it occurs rarely, erythrocyte pyruvate kinase deficiency is a cause of neonatal jaundice and anemia across many ethnic and geographic groups. In this report of a Missouri case, an infant with this condition was also found to have Pelger-Huet leukocyte anomaly.
- 17654506
- Pyruvic acid
- NA
- Case Report
- Summary
- Significant hyperbilirubinaemia, anemia, and splenomegaly are common features in patients with severe haemolysis due to pyruvate kinase (PK) deficiency.
- Pyruvate kinase deficiency associated with severe liver dysfunction in the newborn. American journal of hematology, 2007 Nov [Go to PubMed]
- Significant hyperbilirubinaemia, anemia, and splenomegaly are common features in patients with severe haemolysis due to pyruvate kinase (PK) deficiency. Until now, severe neonatal PK deficiency has not been associated with fatal liver disease at this age. We present two neonatal cases of severe PK deficiency complicated with progressive fatal liver disease. The patients presented with severe haemolysis, progressive cholestasis, and hepatosplenomegaly, and both patients ultimately developed liver failure at a very young age. Despite extensive investigations, no specific explanation for liver disease and failure was found. We suggest that the PK deficiency itself directly led to liver dysfunction.
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1 record(s) for Pyruvic acid Effective in Maintaining Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 20182430
- Pyruvic acid
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- Pyruvate kinase deficiency as a cause of extreme hyperbilirubinemia in neonates from a polygamist community.
- Pyruvate kinase deficiency as a cause of extreme hyperbilirubinemia in neonates from a polygamist community. Journal of perinatology : official journal of the , 2010 Mar [Go to PubMed]
- Neonatal hemolytic jaundice is a risk factor for kernicterus. Pyruvate kinase (PK) deficiency is a rare cause of neonatal hemolytic jaundice, with a prevalence estimated at 1 case per 20,000 births in the United States, but with a higher prevalence among the Amish communities in Pennsylvania and Ohio. We discovered four neonates with PK deficiency born in a small community of polygamists. All four had early, severe, hemolytic jaundice. PK deficiency should be considered in neonates with early hemolytic, Coombs-negative, non-spherocytic jaundice, particularly in communities with considerable consanguinity. Such cases should be recognized early and managed aggressively to prevent kernicterus.