- General Drug Summary
- Drug Name
- Somatropin recombinant
- Description
- Recombinant human growth hormone (somatotropin) 191 residues, MW 22.1 kD, synthesized in E. coli
- Also Known As
- GH; GH-N; Growth hormone; Growth hormone 1; Pituitary growth hormone; Somatotropin precursor; Somatropin
- Categories
- Hormone Replacement
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Somatropin recombinant Adverse Event in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 2586535
- Somatropin recombinant
- Adverse Event
- System Review
- Summary
- Cholestasis and hyperbilirubinemia must be seen in association with growth hormone and cortisol deficiency in the context of pathogenesis.
- [Hypoglycemia and cholestatic jaundice in congenital panhypopituitarism]. Monatsschrift Kinderheilkunde : Organ der Deutsche, 1989 Oct [Go to PubMed]
- The case of a female newborn who was first found to have severe recurrent hypoglycemia and then developed cholestasis with conjugated hyperbilirubinemia is presented. No infectious diseases, metabolic defects, or disease of the hepatobiliary system were found. Endocrinological investigations revealed panhypopituitarism. Hypoplasia or aplasia of the pituitary was suspected. Cholestasis and hyperbilirubinemia must be seen in association with growth hormone and cortisol deficiency in the context of pathogenesis.
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1 record(s) for Somatropin recombinant Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 7623426
- Somatropin recombinant
- Effective in Inducing Remission
- Case Report
- Summary
- Cholestasis can, especially in combination with hypoglycemia, be a first sign of congenital growth hormone deficiency.
- [Long-term follow-up of a boy with recurrent hypoglycemia and cholestasis in congenital growth hormone deficiency]. Klinische Pädiatrie, [Go to PubMed]
- We report on a four-year-old boy with congenital growth hormone deficiency who first presented at age 13 weeks with jaundice and recurrent hypoglycemia. Growth hormone deficiency was diagnosed two years later, after cholestasis and hypoglycemia had almost completely disappeared, but length deficiency became apparent. The reason for the association of cholestasis with growth hormone deficiency remains unexplained. Cholestasis can, especially in combination with hypoglycemia, be a first sign of congenital growth hormone deficiency.