- General Drug Summary
- Description
- A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. [PubChem]
- Also Known As
- Sulfadimethylisoxazole; Sulfafurazol; Sulfafurazole; Sulfaisoxazole; Sulfasoxazole; Sulfisonazole; Sulfisoxasole; Sulfisoxazol; Sulfisoxazole Dialamine; Sulfisoxazole Diolamine; Sulfofurazole; Sulphafurazol; Sulphafurazole; Sulphafurazolum; Sulphaisoxazole; Sulphisoxazol; Sulphofurazole
- Structure
- Summary In Neonatal Jaundice
-
3 record(s) for Sulfisoxazole Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 20216106
- Sulfisoxazole
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Caused a linear increase in UB up to +87% at a concentration of 1.32 mM.
- Displacement of bilirubin from albumin by ibuprofen in vitro. Pediatric research, 2010 Jun [Go to PubMed]
- Ibuprofen binds to plasma albumin and could interfere with the binding of bilirubin in jaundiced newborn infants. Most clinical studies have not shown increased concentrations of unbound bilirubin (UB) in plasma from infants treated with ibuprofen for a patent ductus arteriosus. However, studies in vitro have not been equally conclusive. Plasma were obtained from routine samples from jaundiced newborn infants and pooled. Total and UB were measured with the peroxidase method after addition of ibuprofen or sulfisoxazole as a known bilirubin displacer. Final ibuprofen concentrations varied from 0.43 to 2.6 mM. Bilirubin concentrations were varied from 176 to 708 microM by adding bilirubin to plasma samples. Ibuprofen caused a linear increase in UB up to +54% at a concentration of 1.8 mM, compared with an increase of 87% by sulfisoxazole (1.32 mM). A double reciprocal plot of molar concentrations of bound versus UB at bilirubin concentrations ranging from 176 to 708 microM showed a competitive displacement of biirubin by ibuprofen. The data indicate that ibuprofen is a competitive displacer of bilirubin in vitro. Ibuprofen should be used with caution in premature infants with a significant hyperbilirubinemia.
- 956978
- Sulfisoxazole
- Effective in Inducing Remission
- Clinical Trial
- Summary
- a strong binding competitive inhibitor at secondary albumin-binding sites with its additive effects.
- The effect of paraben preservatives on albumin binding of bilirubin. The Journal of pediatrics, 1976 Sep [Go to PubMed]
- The interaction of methylparaben and propylparaben with bilirubin-albumin complexes was studied using difference spectra, Sephadex gel filtration, red blood cell uptake of bilirubin, and the peroxidase assay. Methylparaben was found to be a weak competitor with bilirubin for binding to primary albumin-binding sites but a strong binding competitor (similar to sulfisoxazole) at secondary sites. The displacing effects of methylparaben and sulfisoxazole were additive. Propylparaben bound to albumin but did not displace bilirubin. Drugs and injectable saline and water preparations which contain methylparaben should be avoided in jaundiced newborn infants when the high-affinity albumin-binding sites approach saturation.
- 15001951
- Sulfisoxazole
- Effective in Inducing Remission
- Review
- Summary
- Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase.
- Effect of ibuprofen on bilirubin-albumin binding. The Journal of pediatrics, 2004 Mar [Go to PubMed]
- Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn infants.
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1 record(s) for Sulfisoxazole Adverse Event in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 11803415
- Sulfisoxazole
- Adverse Event
- Review
- Summary
- The pivotal role that bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for measuring bilirubin when evaluating Neonatal jaundice.
- Bilirubin-albumin binding and free bilirubin. Journal of perinatology : official journal of the , 2001 Dec [Go to PubMed]
- The relevance of plasma bilirubin-albumin binding and, in particular, the nonalbumin-bound or"
fre"
bilirubin concentration to neonatal bilirubin toxicity is controversial. The pivotal role that"
fre"
bilirubin played in the bilirubin toxicity that occurred following administration of sulfisoxazole or benzyl alcohol to jaundiced newborns, and the correlation of"
fre"
bilirubin with bilirubin-induced changes in the auditory brainstem response are strong support for measuring"
fre"
bilirubin when evaluating neonatal jaundice. Reliable methods for measuring"
free bilirubi"
are available, and population reference values are needed to help determine its proper clinical use.
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1 record(s) for Sulfisoxazole Not Effective to Patients in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 21280114
- Sulfisoxazole
- Not Effective to Patients
- In Vitro Study
- Summary
- Sulfisoxazole possess no any significant potential in vitro to increase the UB concentration in plasma from jaundiced newborn infants.
- Displacement of bilirubin from albumin in plasma from jaundiced newborns. An in vitro study of purified Chinese herbal constituents and sulfisoxazole. Phytotherapy research : PTR, 2011 Jul [Go to PubMed]
- The aim of the present study was to clarify the in vitro potential of the purified Chinese herbal constituents LZX-A (neferine), QTJ (sinomenine), YHS (tetrahydropalmitine) and SQZG (notoginsenoside R1) to displace the highly bound bilirubin from albumin binding sites in plasma from jaundiced newborn infants. Sulfisoxazole (1.32 mM) was used as a positive control for bilirubin displacement. The displacing potential of the herbal constituents was investigated at assumed therapeutic concentrations and up to 100 times higher. Total (TB) and unbound (UB) bilirubin in plasma were measured by the peroxidase method. Sulfisoxazole increased the UB concentration in plasma by more than 60%. An increased % displacement of bilirubin was found at higher TB levels confirming the presence also of lower affinity binding sites for bilirubin in plasma. None of the purified herbal constituents showed any bilirubin displacing properties and were unaffected by the level of TB in plasma. The combination of sulfisoxazole and he herbal constituents showed no synergistic effect. It is concluded that none of the investigated purified herbal constituents possess any significant potential in vitro to increase the UB concentration in plasma from jaundiced newborn infants.