- General Drug Summary
- Description
- A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels. Typically supplied in the sodium salt form (76584-70-8). Valproic Acid is also a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers.
- Also Known As
- 2-propylvaleric acid; Di-n-propylacetic acid; Di-n-propylessigsaure; Dipropylacetic acid; n-DPA
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Valproic Acid Adverse Event in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 6426840
- Valproic Acid
- Adverse Event
- Case Report
- Summary
- Acts as a human teratogen.
- Valproic acid and congenital malformations. A case report. Clinical pediatrics, 1984 Jun [Go to PubMed]
- An infant exposed in utero to valproic acid was born with multiple congenital malformations, including duodenal atresia, lumbar vertebral fusion, thoracolumbar scoliosis, renal abnormalities, diastasis recti abdominis, depigmentation of the eyebrows, and a large hemangioma. The child had neonatal hyperbilirubinemia and postnatal growth deficiency. This case report is an addition to the literature implicating valproic acid as a human teratogen.