- General Drug Summary
- Description
- A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. [PubChem]
- Also Known As
- Ascorbate; Ascorbic Acid; L-Ascorbate; L-Ascorbic Acid; L-Lyxoascorbic Acid; L-Xyloascorbic Acid
- Groups
- approved; nutraceutical
- Structure
- Summary In Neonatal Jaundice
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1 record(s) for Vitamin C Effective in Maintaining Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 10540891
- Vitamin C
- Effective in Maintaining Remission
- Review
- Summary
- Essential for the growth and normal function of human body,and the absence of vitamin C results Barlow disease in newborn.
- [Vitamins in pregnancy]. Nihon rinsho. Japanese journal of clinical medicin, 1999 Oct [Go to PubMed]
- Vitamins are essential for the growth and normal function of human body. There are very few reports on vitamin A deficiency in pregnant women and newborn. Vitamin B complex includes various fractions essential to proper nutrition. The absence of vitamin C results Barlow disease in newborn. Vitamin D, the antirachitic Vitamin, is of great importance in safeguarding the mother and fetus from its relation to calcium and phosphorus metabolism. Vitamin E is also useful for the treatment of toxemia of pregnancy, intra-uterine growth retardation (IUGR), and neonatal jaundice. Vitamin K is well known for the protection of neonatal hemorrhage. The 6th recommended dietary allowances for Japanese in 1999 is shown in the table.
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1 record(s) for Vitamin C Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 17625638
- Vitamin C
- Effective in Inducing Remission
- Clinical Trial
- Summary
- An index for assessing the serum antioxidant status.
- Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy. Jornal de pediatria, [Go to PubMed]
- To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns.
Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidative stress index (OSI) and individual oxidant components: malondialdehyde (MDA), and lipid hydroperoxide levels.
Vitamin C, uric acid, total bilirubin and MDA concentration were significantly lower, whereas serum TOS, lipid hydroperoxide and OSI levels were significantly higher after phototherapy (p < 0.05). There were significant positive correlations between serum total bilirubin and MDA (r = 0.434, p = 0.001).
Although the MDA level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress.
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1 record(s) for Vitamin C Not Effective to Patients in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 23105589
- Vitamin C
- Not Effective to Patients
- Clinical Trial
- Summary
- in jaundiced Neonatal after phototherapy,the levels of non-enzymatic antioxidants such as GSH, total thiols and vitamin C were significantly low (p<0.001) as compared to controls and the levels decreased significantly after phototherapy (p<0.001).
- Antioxidant status in neonatal jaundice before and after phototherapy. Indian journal of clinical biochemistry : IJCB, 2006 Mar [Go to PubMed]
- Phototherapy has been related to increased oxidative stress and lipid peroxidation. In the present study, thirty full term jaundiced neonates with appropriate weight were analyzed before and after completion of phototherapy for malondialdehyde (MDA), reduced glutathione (GSH), total thiols, vitamin C and superoxide dismutase (SOD) levels in hemolysate and albumin levels in plasma. These parameters were analyzed in cord blood samples of 20 healthy neonates as control. It was observed that levels of MDA were elevated significantly (p<0.001) in patients as compared to controls and that the levels increased significantly after phototherapy (p<0.001). Levels of SOD were also found to be increased significantly as compared to controls and the levels rose after phototherapy (p<0.001). On the other hand, the levels of non-enzymatic antioxidants such as GSH, total thiols and vitamin C were significantly low (p<0.001) as compared to controls and the levels decreased significantly after phototherapy (p<0.001). The plasma albumin levels also were found to be decreased significantly after phototherapy (p<0.01). Therefore, phototherapy increases oxidative stress and should be used with care.