- General Drug Summary
- Description
- A generic descriptor for all tocopherols and tocotrienols that exhibit alpha-tocopherol activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of isoprenoids. [PubChem]
- Also Known As
- alpha-Tocopherol; Tocopherol
- Groups
- approved; nutraceutical
- Structure
- Summary In Neonatal Jaundice
-
11 record(s) for Vitamin E Effective in Inducing Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 7393270
- Vitamin E
- Effective in Inducing Remission
- Clinical Trial
- Summary
- May ameliorating acute hemolytic crises or in reducing morbidity from Neonatal jaundice in this relatively common enetic disorder.
- Reduced chronic hemolysis during high-dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiency. The New England journal of medicine, 1980 Aug 21 [Go to PubMed]
- The observation that high-dose oral vitamin E supplementation (800 IU per day) improved red-cell survival in two rare disorders associated with increased red-cell susceptibility to oxidative stress prompted a similar trial in 23 patients with Mediterranean glucose-6-phosphate dehydrogenase (G6PD) deficiency. Three months of vitamin E administration resulted in decreased chronic hemolysis as evidenced by improved red-cell life span (P less than 0.025), with an improvement in red-cell half-life from 22.9 +/- 0.7 days to 25.1 +/- 0.6 days (mean +/- S.E.M.), increased hemoglobin concentration (P less than 0.001), and decreased reticulocytosis (P less than 0.001) as compared with base-line values. Evaluation after one year of vitamin E administration demonstrated sustained improvement in all these indexes. Controlled clinical trials of vitamin E supplementation may be warranted to examine its efficacy in ameliorating acute hemolytic crises or in reducing morbidity from neonatal jaundice in this relatively common enetic disorder.
- 8483259
- Vitamin E
- Effective in Inducing Remission
- Review
- Summary
- Protection of neonatal hemorrhage ,have clearly therapeutic value to a large number of diseases for example, sterility, toxemia of pregnancy, IUGR, Neonatal jaundice, climacteric syndrome.
- [The fat soluble vitamins in obstetrics and gynecology]. Nihon rinsho. Japanese journal of clinical medicin, 1993 Apr [Go to PubMed]
- The therapeutic use of vitamin D in the OB-GYN field is well known for osteoporosis in the climacteric stage, and vitamin K is for the protection of neonatal hemorrhage. The therapeutic use of vitamin E was reviewed, and it was concluded that there was a large number of diseases for example, sterility, toxemia of pregnancy, IUGR, neonatal jaundice, climacteric syndrome, in which a therapeutic value for vitamin E could be clearly establish, vitamin K prophylaxis is also under taken for the neonate. This can be done by giving a dose to the mother just before or in the early stages of labor. Ubiquinone, was given to the man for the treatment of oligospermia. CoQ10 also warrants further investigation for the treatment of fetal arrhythmia in utero.
- 7752007
- Vitamin E
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Can be a prooxidant in isolated lipoprotein suspensions,may act as a prooxidant in lipid emulsions, as it is in lipoprotein suspensions.
- Oxidation of parenteral lipid emulsion by ambient and phototherapy lights: potential toxicity of routine parenteral feeding. The Journal of pediatrics, 1995 May [Go to PubMed]
- Vitamin E can be a prooxidant in isolated lipoprotein suspensions. Because lipid emulsions used in parenteral nutrition are lipoprotein-like suspensions rich in polyunsaturated fatty acids and vitamin E, we hypothesized that vitamin E may act as a prooxidant in lipid emulsions, as it is in lipoprotein suspensions. We therefore exposed an intravenously administered lipid emulsion (Intralipid) to a single spotlight commonly used in the treatment of neonatal jaundice, and measured the formation of triglyceride hydroperoxides by using high-performance liquid chromatography with postcolumn chemiluminescence detection. Concentrations of these hydroperoxides in different batches of fresh intralipid were usually approximately 10 mumol/L but increased up to 60 times after exposure to phototherapy light for a period of 24 hours, even though significant amounts of vitamin E were present at the end of the exposure. Triglyceride hydroperoxides were formed during phototherapy light exposure whether the intralipid was in pastic tubing used routinely for infusion or in glass containers. Ambient light also caused significant peroxidation of the formula lipids, although to a much lesser extent than observed with phototherapy light. For infants in the neonatal intensive care unit who were receiving intralipid but not phototherapy, solutions being infused at the end of 24 hours contained a mean of 40 mumol/L hydroperoxides. For infants receiving phototherapy, the mean was 97 mumol/L. Phototherapy light-induced formation of triglyceride hydroperoxides was prevented by covering the intralipid with aluminum foil or supplementation with sodium ascorbate before light exposure. We conclude that intralipid is highly susceptible to oxidation and that elevated levels of oxidized lipids can be formed during its clinical use, especially when intralipid infusion is combined with phototherapy. Because lipid hydroperoxides are cytotoxic and can cause adverse effects, inadvertent infusion of rancid intralipid may add to the numerous problems encuntered by premature neonates.
- 1421889
- Vitamin E
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Potential preventive effect on sister chromatid exchange (SCE).
- Sister chromatid exchanges in peripheral lymphocytes in newborns treated with phototherapy and vitamin E. Acta paediatrica (Oslo, Norway : 1992), 1992 Oct [Go to PubMed]
- A study was undertaken to determine whether blue fluorescent light might affect the sister chromatid exchange (SCE) frequency of peripheral lymphocytes in icteric newborns undergoing continuous phototherapy treatment (72 h). Also, the potential preventive effect of vitamin E on SCE frequency was studied in a subgroup of 11 preterm and 9 fullterm newborns after daily administration of vitamin E (46.44 mumol/kg/d, im). The results revealed that only the preterm icteric newborns showed an increase in mean SCE frequency of peripheral lymphocytes after phototherapy (9%, p = 0.02), but in no case did the highest SCEs/cell ratio exceed the normal values. No correlation was found between the average SCE rate and birth weight, gestational age or bilirubin levels. Also, no difference in SCEs was observed between newborns treated or untreated with vitamin E.
- 7195802
- Vitamin E
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Influence susceptibility of RBCs to H2O2 haemolysis but show little effect on the occurrence of physiological jaundice.
- Dietary vitamin E and polyunsaturated fatty acid (PUFA) in newborn babies with physiological jaundice. Early human development, 1981 May [Go to PubMed]
- We studied 69 term babies aged 2-8 days who had physiological jaundice and who were fed formula A (Ostermilk Complete; vitamin E, 0.46 mg per 100 ml; polyunsaturated fatty acid (PUFA), approximately 0.08 g per 100 ml), or formula B (Cow and Gate Premium; vitamin E, 1.0 mg per 100 ml; PUFA, approximately 0.55 g per 100 ml) or breast milk. Babies fed formula B, with the greatest vitamin E and PUFA content, had a significantly higher mean plasma vitamin E level compared with those fed formula A, even as early as the second and third day. Breast fed babies, 2-3 days old, had a lower mean plasma vitamin E level compared with formula B fed babies, thereafter vitamin E levels in breast fed babies rose. The RBCs of babies fed formula B and breast milk were significantly less susceptible to hydrogen peroxide (H2O2) haemolysis compared with the RBCs of those fed formula A. Reduced susceptibility to H2O2 haemolysis in formula B fed babies was observed in those as young as 2-3 days. Susceptibility to H2O2 haemolysis didnot correlate with haemoglobin concentration, plasma bilirubin nor with the reticulocyte count in babies on different feeds. We conclude that in term newborn babies the vitamin E and PUFA contents of the milk feeds influence plasma vitamin E levels and susceptibility of RBCs to H2O2 haemolysis, but do not have an important bearing on the occurrence of physiological jaundice.
- 7133335
- Vitamin E
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Play a great effect on progressive neurological syndrome characterized mainly by dysarthria and ataxia.
- Progressive neurological disorder associated with obstructive jaundice and vitamin E deficiency. Neuropediatrics, 1982 Aug [Go to PubMed]
- A ten-year-old girl had obstructive jaundice in the newborn period which persisted for 4 years despite choledochojejunostomy at 6 weeks. From the age of 6 years she developed a progressive neurological syndrome characterized mainly by dysarthria and ataxia. A causal relationship with her profound vitamin E deficiency seemed likely. Treatment with vitamin E over a 2 1/2 year period appeared to arrest the progression of the neurological deficit and subsequent increase in dosage produced some improvement in her ataxia.
- 4061425
- Vitamin E
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Effective medication in infants in whom cholestasis is diagnosed at early age.
- Frequency and clinical progression of the vitamin E deficiency neurologic disorder in children with prolonged neonatal cholestasis. American journal of diseases of children (1960), 1985 Dec [Go to PubMed]
- To determine the frequency of biochemical vitamin E deficiency and of the clinical signs of the vitamin E deficiency neurologic syndrome in children with prolonged neonatal cholestatic disorders, we studied 46 children (aged 1 month to 17.0 years) with chronic forms of intrahepatic neonatal cholestasis and 47 children (aged 4 months to 8.0 years) with extrahepatic biliary atresia. Based on serum vitamin E concentrations and the ratios of serum vitamin E concentration to total serum lipid concentration, 64% of the intrahepatic and 77% of the extrahepatic cholestasis groups were vitamin E deficient. Prior to age 1 year, neurologic function was normal in all children. Between ages 1 and 3 years, neurologic abnormalities were present in approximately 50% of the vitamin E-deficient children; after age 3 years, neurologic abnormalities were present in all vitamin E-deficient children. Areflexia was the first abnormality to develop between ages 1 and 4 years; truncal and limb ataxia, peripheral neuropathy, and ophtalmoplegia developed between ages 3 and 6 years. Neurologic dysfunction progressed to a disabling combination of findings by ages 8 to 10 years in the majority of vitamin E-deficient children. Neurologic function was normal in the vitamin E-sufficient children. We conclude that vitamin E status should be evaluated in infants in whom cholestasis is diagnosed, and effective therapy should be initiated to prevent or treat vitamin E deficiency at an early age.
- 3906255
- Vitamin E
- Effective in Inducing Remission
- Review
- Summary
- Decrease the severity of retrolental fibroplasia of prematures ,decrease the frequency of intraventricular hemorrhage,effect on the metabolism of prostaglandins.
- [Recent aspects of vitamin E in pediatrics]. Klinische Pädiatrie, [Go to PubMed]
- New aspects of vitamin E metabolism have demonstrated new indications for its use in pediatrics. With respect to the retrolental fibroplasia of prematures under intensive care it can be stated that vitamin E does not necessarily prevent this complication but surely can decrease its severity. For the intensive care of newborns it is of importance that vitamin E is apparently able to decrease the frequency of intraventricular hemorrhage. The effect of vitamin E on the metabolism of prostaglandins opens new insights in the understanding of thrombocyte aggregation and atherogenesis. There may be a possible indication for the substitution of vitamin E in patients with diabetes mellitus type I.
- 3320325
- Vitamin E
- Effective in Inducing Remission
- Randomized Controlled Trial
- Summary
- Supplemental oral vitamin E therapy has no major effect on bilirubin production during the first 3 days of life in premature infants weighing less tha 1,500 g at birth.
- Carboxyhemoglobin concentration as an index of bilirubin production in neonates with birth weights less than 1,500 grams: a randomized double-blind comparison of supplemental oral vitamin E and placebo. Journal of pediatric gastroenterology and nutritio, [Go to PubMed]
- A randomized double-blind study of the efficacy of oral vitamin E supplementation as a prophylactic treatment for hyperbilirubinemia was undertaken in preterm infants weighing less than 1,500 g. Hemoglobin (Hb) levels, blood carboxyhemoglobin saturation (HbCOc), end-tidal carbon monoxide concentration (ETCO), and serum total bilirubin levels were determined in each subject on the first and third days of the study. We found no differences between the vitamin E-treated and placebo-treated groups with respect to Hb, HbCOc, ETCO, or serum bilirubin levels on day 1 or 3. In addition, we reanalyzed our data to compare those infants who had low vitamin E levels at birth with those who had vitamin E levels greater than 0.4 mg/dl on day 1. We still observed no differences in Hb, HbCOc, ETCO, or serum bilirubin levels on day 1 or 3. The results of our study suggest that supplemental oral vitamin E therapy has no major effect on bilirubin production during the first 3 days of life in premature infants weighing less tha 1,500 g at birth.
- 481976
- Vitamin E
- Effective in Inducing Remission
- Clinical Trial
- Summary
- Infants with birthweights less than or equal to 1500 gm who received vitamin E demonstrated a significant decrease in serum bilirubin on day 3 of life as well as a significant decrease in peak serum bilirubin during the first week of life .
- Vitamin E and neonatal bilirubinemia. Pediatrics, 1979 Sep [Go to PubMed]
- A study was designed to determine the effect of vitamin E on bilirubinemia in the preterm infant. Twenty infants with birth weight between 1,000 and 1,500 gm and 20 infants with birth weights between 1,501 and 2,000 gm were studied. Half the infants in each birth weight group received vitamin E administered intramuscularly in a total dose of 50 mg/kg during days 1 to 3 of life; the remaining infants served as controls. The administration of vitamin E produced significantly increased plasma tocopherol concentrations and normal hydrogen peroxide hemolysis tests by the end of the first week of life. Infants with birthweights less than or equal to 1500 gm who received vitamin E demonstrated a significant decrease in serum bilirubin on day 3 of life (6.5 +/- 2.2 vs 8.8 +/- 2.2 mg/dl) as well as a significant decrease in peak serum bilirubin during the first week of life (8.3 +/- 2.2 vs 10.6 +/- 2.6 mg/dl). The duration of phototherapy also was significantly less in the vitamin E-supplemented group (48 +/- 18 vs 17 +/- 31 hours). These differences were less pronounced in infants with birth weights more than 1,500 gm.
- 386215
- Vitamin E
- Effective in Inducing Remission
- Review
- Summary
- Acting as a free radical scavenger may be important in the prevention of oxygen toxicity both to the eye (retrolental fibroplasia) as well as ameliorating the oxygen component of the destructive effects of respirator lung disease (bronchopulmonary dysplasia).
- Current advances in perinatal medicine. Paediatrician, 1979 [Go to PubMed]
- The enhancement of pulmonary maturation with the resultant ability to prevent hyaline membrane disease has given rise to the use of a number of drugs experimentally including corticosteroids, thyroxine, aminophylline, heroin, and several suggested others for this purpose. In clinical use to date only the corticosteroids have been widely utilized in man but it is clear that these agents are capable of effecting an advancement in the maturation of the surfactant system of the lung and a subsequent reduction in the incidence of severity of hyaline membrane disease. However, all agents which act by the enhancement of maturation also carry with them a resultant arrest to replication of tissues and there have been demonstrable effects on both the lung and possibly the brain of the organisms to whom these agents have been administreted. In this connection it is, therefore, important to realize that the advantages gained from these agents may be counterbalanced by disadvantages from their usage and that a reasoned ad careful approach in each individual case is mandatory when use of such agents is considered. Experimental and clinical studies suggest the possibility that Vitamin E acting as a free radical scavenger may be important in the prevention of oxygen toxicity both to the eye (retrolental fibroplasia) as well as ameliorating the oxygen component of the destructive effects of respirator lung disease (bronchopulmonary dysplasia). The action of Vitamin E under these circumstances is not dependent upon its actual quantitative level in the plasma of premature infants but in utilization to its excess. Although phototherapy has been universally and widely used since 1958, precise studies of its mechanism of action have not been revealing. Recent work has suggested that following exposure to photoirradiation, bilirubin in its unconjugated form can be seen to appear in the excretory bile ducts suggesting the transport of unconjugated bilirubin through the liver. More recent evidence has also suggested that this occurrenc is the result of internal rotation following light exposure of one of the double bonded rings which effectively converts the molecule from a lipid soluble to a water soluble and thereby excretable form. These studies would not only account for an appropriate explanation of the quantitative reduction in bilirubin observed but carry with them the other important consideration that the amount of light exposure necessary to accomplish this is strikingly less than the previously considered photooxidation reaction. The clinical implications of these findings may suggest a reevaluation of the quanta of light which has been used for purposes of phototherapy to date.
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4 record(s) for Vitamin E Effective in Maintaining Remission in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 10540891
- Vitamin E
- Effective in Maintaining Remission
- Review
- Summary
- Essential for the growth and normal function of human body,and is also useful for the treatment of toxemia of pregnancy, intra-uterine growth retardation (IUGR), and Neonatal jaundice.
- [Vitamins in pregnancy]. Nihon rinsho. Japanese journal of clinical medicin, 1999 Oct [Go to PubMed]
- Vitamins are essential for the growth and normal function of human body. There are very few reports on vitamin A deficiency in pregnant women and newborn. Vitamin B complex includes various fractions essential to proper nutrition. The absence of vitamin C results Barlow disease in newborn. Vitamin D, the antirachitic Vitamin, is of great importance in safeguarding the mother and fetus from its relation to calcium and phosphorus metabolism. Vitamin E is also useful for the treatment of toxemia of pregnancy, intra-uterine growth retardation (IUGR), and neonatal jaundice. Vitamin K is well known for the protection of neonatal hemorrhage. The 6th recommended dietary allowances for Japanese in 1999 is shown in the table.
- 2371129
- Vitamin E
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- The efficacy of PT turned out enhanced on its combination with alpha-tocopherol acetate.
- [Comparative evaluation of the effectiveness of various schedules of phototherapy in premature newborn infants with hyperbilirubinemia]. Pediatriia, 1990 [Go to PubMed]
- As many as 118 premature neonates weighing from 900 to 2500 g at birth, afflicted with hyperbilirubinemia were examined. In 80 children, the use of phototherapy (PT) appeared an indispensable condition of the treatment of jaundice. The regimen of radiation varied: 28 children received intermittent treatment lasting 24 hours; 52 children were given continuous treatment, with the period of radiation amounting to 48 or 72 hours. Part of the children were on PT combined with alpha-tocopherol acetate. Bilirubin concentration in the blood serum, lipid peroxidation, the lipid and phospholipid spectra of red blood cell membranes were used as criteria for the treatment efficacy. The highest therapeutic effect was attained in the children who received continuous radiation lasting 48 hours. The efficacy of PT turned out enhanced on its combination with alpha-tocopherol acetate.
- 7407278
- Vitamin E
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- The level of Vitamin E seems no differences between newborn infants before and after phototherapy.
- Vitamin E serum levels in newborn infants undergoing phototherapy. Biology of the neonate, 1980 [Go to PubMed]
- The serum vitamin E levels of 11 full-term and 10 premature infants, jaundiced and subjected to phototherapy, were measured and compared wth 9 premature and 10 full-term jaundiced control infants. No differences were observed before or after phototherapy or 1 week after stopping it. The same negative results were noted in the two groups of infants regarding the values of microhematocrit, Hb and reticulocytes.
- 575929
- Vitamin E
- Effective in Maintaining Remission
- Clinical Trial
- Summary
- Vitamin E deficiency might be a factor in the aetiology of the anaemia of prematurity, prior subjection to exchange transfusion is unlikely to make a significant contribution to the vitamin E deficiency.
- Exchange transfusion and serum vitamin E (tocopherol) concentration in the newborn. Early human development, 1977 Oct [Go to PubMed]
- 17 babies suffering from haemolytic disease or"
hyperbilirubinaemia of prematurit"
underwent exchange transfusion in the first 4 days of life. In 14 babies, including all those who had abnormally low pre-exchange serum vitamin E levels (<0.5 mg/100 ml), the vitamin E concentration rose as a result of exchange transfusion. In 3 babies the serum vitamin E concentration fell as result of exchange transfusion, but in no case was the post-exchange level below 0.5 mg/100 ml. The normal range of plasma vitamin E in stored ACD blood was 0.44--1.24 mg/100 ml. It was concluded that although vitamin E deficiency might be a factor in the aetiology of the anaemia of prematurity, prior subjection to exchange transfusion is unlikely to make a significant contribution to the vitamin E deficiency.
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1 record(s) for Vitamin E Chemoprevention in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 7293869
- Vitamin E
- Chemoprevention
- Clinical Trial
- Summary
- On these basis of prophylaxis has been attempted by treating newborns with folic acid, alpha-tocopherol and vitamins B1, B2, B6 and C.
- [Vitamin prophylaxis for immature infant anemia (author's transl)]. Acta vitaminologica et enzymologica, 1980 [Go to PubMed]
- The cause of the Premature Infant Anemia (PIA) is mainly an insufficient erythropoiesis, a shorter mean-life of the red cells and in increased hemolysis. On these basis of prophylaxis has been attempted by treating newborns with folic acid, alpha-tocopherol and vitamins B1, B2, B6 and C. 208 premature babies have been treated (birth weight higher than 1750 nr. 171; birth weight less than 1750 nr. 37). Several parameters have been evaluated: weight gain, erythrocyte and reticulocyte count, jaundice occurrence and number of transfusions needed. The results on the blood parameters was good for the small babies group and sufficient for the others. Differences have been observed between the two groups for the occurrence of jaundice and transfusions.
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1 record(s) for Vitamin E Not Effective to Patients in Neonatal Jaundice.
- PMID
- Drug Name
- Efficacy
- Evidence
- 10798124
- Vitamin E
- Not Effective to Patients
- In Vitro Study
- Summary
- Serum vitamin E levels were not different before and after 72 h of phototherapy in both preterm and term infants.phototherapy would preferably seem to be safe and efficient method oftreatment for all neonates presenting with hyperbilirubinemia.
- Antioxidant defense systems in newborns undergoing phototherapy. Indian journal of pediatrics, [Go to PubMed]
- This paper was designed to investigate whether phototherapy is an oxidative stress in newborn infants undergoing phototherapy. A day-light continuous phototherapy was given to jaundiced 20 term and 16 preterm newborns for 72 hours. We measured serum vitamin E and the activities of red blood cell anti-oxidation enzymes (superoxide dismutase, catalase and glutathione peroxidase) before and after 72 h of phototherapy. Serum vitamin E levels were not different before and after 72 h of phototherapy in both preterm and term infants. In several studies, antioxidant enzyme activities have been shown to increase in response to oxidative stresses. In this study, however, the antioxidant enzyme activities in the hemolysate were similar before and at the end of the phototherapy in both preterm and full term. In conclusion, the results of our in vivo study do not confirm the thesis that phototherapy is an oxidative stress in newborn infants. Therefore, phototherapy would preferably seem to be safe and efficient method oftreatment for all neonates presenting with hyperbilirubinemia.