Selected works:

Chen W#, Chen X#, Yao L#, Feng J, Li F, Shan Y, Ren L, Zhuo C, Feng M, Zhong S*,He C*. A global view of altered ligand-receptor interactions in bone marrow aging based on single-cell sequencing. Comput Struct Biotechnol J. 2024 Jun 20;23:2754-2762.

Shao L*, Jiang GT*, Yang XL, Zeng ML, Cheng JJ, Kong S, Dong X, Chen TX, Han S, Yin J, Liu WH, He XH, He C#, Peng BW#. Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy. FASEB J. 2021 Feb;35(2):e21330. doi: 10.1096/fj.202001737RR.

Xu X*, Zhang J*, Tian Y*, Gao Y*, Dong X, Chen W, Yuan X, Yin W, Xu J, Chen K#, He C#, Wei L#. CircRNA inhibits DNA damage repair by interacting with host gene. Mol Cancer. 2020 Aug 24;19(1):128. doi: 10.1186/s12943-020-01246-x.

Xiao S*, Cao S*, Huang Q*, Xia L*, Deng M, Yang M, Jia G, Liu X, Shi J, Wang W, Li Y, Liu S, Zhu H, Tan K, Luo Q, Zhong M#, He C#, Xia L#. The RNA m⁶A modification landscape of human fetal tissue. Nature Cell Biology. 2019 Apr 29. doi: 10.1038/s41556-019-0315-4.

Feng J*#, Chen K*, Dong X*, Xu X, Jin Y, Zhang X, Chen W, Han Y, Shao L, Gao Y, He C#. Genome-wide identification of cancer-specific alternative splicing in circRNA. Mol Cancer. 2019 Mar 8; 18(1):35. doi: 10.1186/s12943-019-0996-0. PubMed PMID: 30849979.

Han Y*, Feng J*, Xia L*, Dong X, Zhang X, Zhang S, Miao Y, Xu Q, Xiao S, Zuo Z, Xia L, He C#. CVm6A: A Visualization and Exploration Database for m⁶As in Cell Lines. Cells. 2019 Feb 17; 8(2). pii: E168. doi: 10.3390/cells8020168. PubMed PMID: 30781586.

Xia S*, Feng J*, Chen K*, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, Wei L, Han L#, He C#. CSCD: A database for cancer-specific circular RNAs. Nucleic Acids Research. 2018 Jan 4. doi: 10.1093/nar/gkx863.

Feng J*, Xiang Y*, Xia S*, Liu H, Wang J, Ozguc F, Lei L, Kong R, Diao L, He C#, Han L#. CircView: a visualization and exploration tool for circular RNAs. Briefings in Bioinformatics. 2017 Jun 30. doi: 10.1093/bib/bbx070.

Lei L*, Xia S*, Liu D*, Li X*, Feng J, Zhu Y, Hu J, Xia L, Guo L, Chen F, Cheng H, Chen K, Hu H, Chen X, Li F, Zhong S, Mittal N, Yang G, Qian Z, Han L#, He C#. Genome-wide characterization of lncRNAs in acute myeloid leukemia. Briefings in Bioinformatics. 2017 Feb 15. doi: 10.1093/bib/bbx007.

Xia S*, Feng J*, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L#, He C#. Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Briefings in Bioinformatics. 2017 Nov 1. doi: 10.1093/bib/bbw081.

He C*#, Hu H*, Wilson KD*, Wu H, Feng J, Xia S, Churko J, Qu K, Chang HY, Wu JC#. Systematic Characterization of Long Non-Coding RNAs Reveals the Contrasting Coordination of Cis- and Trans- Molecular Regulation in Human Fetal and Adult Heart. Circulation Cardiovascular Genetics. 2016 Feb 19. pii: CIRCGENETICS.115.001264.

Li Z*, Herold T*, He C*, Valk PJ, Chen P, Jurinovic V, Mansmann U, Radmacher MD, Maharry KS, Sun M, Yang X, Huang H, Jiang X, Sauerland MC, Büchner T, Hiddemann W, Elkahloun A, Neilly MB, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Döhner K, Bullinger L, Liu PP, Delwel R, Marcucci G, Lowenberg B, Bloomfield CD, Rowley JD, Bohlander SK, Chen J. Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study. Journal of Clinical Oncology. 2013 Mar 20;31(9):1172-81. doi: 10.1200/JCO.2012.44.3184.

He C*, Li Z*, Chen P*, Huang H, Hurst LD, Chen J. Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution. Nucleic Acids Research. 2012 May;40(9):4002-12. doi: 10.1093/nar/gkr1312.

Mi S*, Li Z*, Chen P*, He C*, Cao D, Elkahloun A, Lu J, Pelloso LA, Wunderlich M, Huang H, Luo RT, Sun M, He M, Neilly MB, Zeleznik-Le NJ, Thirman MJ, Mulloy JC, Liu PP, Rowley JD, Chen J. Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3710-5. doi: 10.1073/pnas.0914900107.

He C*, Zhou F, Zuo Z, Cheng H, Zhou R. A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis. PLoS One. 2009;4(3):e4732. doi: 10.1371/journal.pone.0004732.

He C*, Cheng H, Zhou R. GATA family of transcription factors of vertebrates: phylogenetics and chromosomal synteny. Journal of Biosciences. 2007 Dec;32(7):1273-80.

He C*, Zuo Z, Chen H, Zhang L, Zhou F, Cheng H, Zhou R. Genome-wide detection of testis- and testicular cancer-specific alternative splicing. Carcinogenesis. 2007 Dec;28(12):2484-90.

Chen G, Yuan C, Duan F, Liu Y, Zhang J, He Z, Huang H, He C, Wang H. IGF1/MAPK/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats. Toxicol Appl Pharmacol. 2018 Jan 14. pii: S0041-008X(18)30008-5. doi: 10.1016/j.taap.2018.01.008.

Chen X, Loo JX, Shi X, Xiong W, Guo Y, Ke H, Yang M, Jiang Y, Xia S, Zhao M, Zhong S, He C, Fu L, Li F. E6 protein expressed by high-risk HPV activates super-enhancers of the EGFR and c-MET oncogenes by destabilizing the histone demethylase KDM5C. Cancer Res. 2018 Jan 16. pii: canres.2118.2017. doi: 10.1158/0008-5472.CAN-17-2118.

Jiang X, Hu C, Ferchen K, Nie J, Cui X, Chen CH, Cheng L, Zuo Z, Seibel W, He C, Tang Y, Skibbe JR, Wunderlich M, Reinhold WC, Dong L, Shen C, Arnovitz S, Ulrich B, Lu J, Weng H, Su R, Huang H, Wang Y, Li C, Qin X, Mulloy J, Zheng Y, Diao J, Jin J, Li C, Liu PP, He C, Chen Y, Chen J. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099. doi: 10.1038/s41467-017-02290-w.

Liang P, Sallam K, Wu H, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churko J, Hu S, Sharma A, Lam CK, Scheinman MM, Bers DM, Wu JC. Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome. J Am Coll Cardiol. 2016 Nov 8;68(19):2086-2096. doi: 10.1016/j.jacc.2016.07.779. PubMed PMID: 27810048.

Chen J, Zhuang Y, Zhang ZF, Wang S, Jin P, He C, Hu PC, Wang ZF, Li ZQ, Xia GM, Li G, Wang Y, Wan Q. Glycine confers neuroprotection through microRNA-301a/PTEN signaling. Mol Brain. 2016 May 26;9(1):59. doi:10.1186/s13041-016-0241-3. PubMed PMID: 27230112.

Mukherjee D, Lu H, Yu L, He C, Lahiri SK, Li T, Zhao J. Krüppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis. Oncotarget. 2016 Mar 14. doi: 10.18632/oncotarget.8083.

Gu M, Mordwinkin NM, Kooreman NG, Lee J, Wu H, Hu S, Churko JM, Diecke S, Burridge PW, He C, Barron FE, Ong SG, Gold JD, Wu JC. Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. Eur Heart J. 2015 Apr 1;36(13):806-16. doi: 10.1093/eurheartj/ehu411.

Huang H, Jiang X, Li Z, Li Y, Song CX, He C, Sun M, Chen P, Gurbuxani S, Wang J, Hong GM, Elkahloun AG, Arnovitz S, Wang J, Szulwach K, Lin L, Street C, Wunderlich M, Dawlaty M, Neilly MB, Jaenisch R, Yang FC, Mulloy JC, Jin P, Liu PP, Rowley JD, Xu M, He C, Chen J. TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11994-9. doi: 10.1073/pnas.1310656110.

Chen P, Price C, Li Z, Li Y, Cao D, Wiley A, He C, Gurbuxani S, Kunjamma RB, Huang H, Jiang X, Arnovitz S, Xu M, Hong GM, Elkahloun AG, Neilly MB, Wunderlich M, Larson RA, Le Beau MM, Mulloy JC, Liu PP, Rowley JD, Chen J. miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11511-6. doi: 10.1073/pnas.1310144110.

Sharma A, Diecke S, Zhang WY, Lan F, He C, Mordwinkin NM, Chua KF, Wu JC. The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem. 2013 Jun 21;288(25):18439-47. doi: 10.1074/jbc.M112.405928.

Li Z, Zhang Z, Li Y, Arnovitz S, Chen P, Huang H, Jiang X, Hong GM, Kunjamma RB, Ren H, He C, Wang CZ, Elkahloun AG, Valk PJ, Döhner K, Neilly MB, Bullinger L, Delwel R, Löwenberg B, Liu PP, Morgan R, Rowley JD, Yuan CS, Chen J. PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood. 2013 Feb 21;121(8):1422-31. doi: 10.1182/blood-2012-07-442004.

Jiang X, Huang H, Li Z, He C, Li Y, Chen P, Gurbuxani S, Arnovitz S, Hong GM, Price C, Ren H, Kunjamma RB, Neilly MB, Salat J, Wunderlich M, Slany RK, Zhang Y, Larson RA, Le Beau MM, Mulloy JC, Rowley JD, Chen J. MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19397-402. doi: 10.1073/pnas.1217519109.

Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, Wang J, Arnovitz S, Elkahloun A, Price C, Hong GM, Ren H, Kunjamma RB, Neilly MB, Matthews JM, Xu M, Larson RA, Le Beau MM, Slany RK, Liu PP, Lu J, Zhang J, He C, Chen J. Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell. 2012 Oct 16;22(4):524-35. doi: 10.1016/j.ccr.2012.08.028.

Li Z, Huang H, Chen P, He M, Li Y, Arnovitz S, Jiang X, He C, Hyjek E, Zhang J, Zhang Z, Elkahloun A, Cao D, Shen C, Wunderlich M, Wang Y, Neilly MB, Jin J, Wei M, Lu J, Valk PJ, Delwel R, Lowenberg B, Le Beau MM, Vardiman J, Mulloy JC, Zeleznik-Le NJ, Liu PP, Zhang J, Chen J. miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun. 2012 Feb 21;3:688. doi: 10.1038/ncomms1681.

Li Z, Huang H, Li Y, Jiang X, Chen P, Arnovitz S, Radmacher MD, Maharry K, Elkahloun A, Yang X, He C, He M, Zhang Z, Dohner K, Neilly MB, Price C, Lussier YA, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Bullinger L, Valk PJ, Delwel R, Lowenberg B, Liu PP, Marcucci G, Bloomfield CD, Rowley JD, Chen J. Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. Blood. 2012 Mar 8;119(10):2314-24. doi: 10.1182/blood-2011-10-386235.

Wang Y, Li Z, He C, Wang D, Yuan X, Chen J, Jin J. MicroRNAs expression signatures are associated with lineage and survival in acute leukemias. Blood Cells Mol Dis. 2010 Mar 15;44(3):191-7. doi: 10.1016/j.bcmd.2009.12.010.